You can pick the days that work best with your schedule. Rebif injections should be taken on the same three days a week. Injections should be at least 48 hours apart. Many people choose to take their injections on Monday, Wednesday, and Friday so that they have injection free weekends. After you decide which three days work best for your lifestyle, stick with those to help make your injections part of your weekly routine. If you accidentally take more than your prescribed dose, call your doctor right away.

Rebif is given by subcutaneous (under the skin) injection, as opposed to intramuscular (into the muscle) injection. With Rebif, you only have to put the needle right beneath your skin, and Rebif now uses a 29-gauge needle — the thinnest of any MS therapy.

Rebif comes ready to use, in syringes that already contain the medicine and do not require needle assembly, so you don't have to worry about mixing any solutions before injection. Monthly supplies of Rebif syringes are provided.

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