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Timothy L. Vollmer, MD
Department of Neurology
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Multiple Sclerosis Institute
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Weill Medical College of Cornell University

Clinical Attending in Neurology,
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How To Reduce The Side
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This Is My 1st Column, It's About Being In A Trial For Alemtuzumab (Campath)
This Pill Got Rid of
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Sunday

 

Safety and immunogenicity of a new formulation of interferon -1a (Rebif® New Formulation) in a Phase IIIb study in patients with relapsing ms

Background: A new formulation of subcutaneous (s.c.) interferon--1a has been developed (Rebif® New Formulation, RNF), produced without fetal bovine serum and without human serum albumin as an excipient, with the aim of improving injection tolerability, and reducing immunogenicity.
Objectives: This article reports 96-week analyses of a Phase IIIb, open-label study of the safety and immunogenicity of RNF compared with historical (EVIDENCE study) and recent (REGARD study) data on the original formulation.

Conclusions: RNF has improved overall immunogenicity and safety profiles compared with the original formulation.

Sage Publications
CLICK HERE FOR FULL ABSTRACT



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