Latest Comments
From Subject Time Posted
1 NEW! » Jeannine Elan Extends Tysabri's Reach to Canada Oct 8 2006 07:46
1 NEW! » Jeannine 10 Top Australian Scientists Predict Major Medical Advances in MS (download free report) Oct 10 2006 13:11
1 NEW! » Jeannine NEUROVAX: PRESS RELEASE FROM IMMUNE RESPONSE CORP. Oct 10 2006 13:06
1 NEW! » "Gamma Julie" Should Job Hunters Reveal Chronic Illness? The Pros and Cons..[update] Oct 31 2006 03:41
1 NEW! » Jeannine HUMAN STEM CELLS DELAY START OF LOU GEHRIG'S DISEASE IN RATS Oct 15 2006 10:02
1 NEW! » Jeannine Tysabri and Avonex add customer service reps Oct 17 2006 07:34
1 NEW! » Jeannine "Take 10 laps and call me in the morning" Oct 17 2006 09:15
1 NEW! » Jeannine "inmate moved to hospital" (AN UPDATE OF LAST WEEKS STORY: "INMATE WITH MS" Oct 17 2006 09:42
1 NEW! » Jeannine Fampridine SR - NEW DRUG IN PIPELINE Oct 18 2006 09:42
1 NEW! » Jeannine [PROFESSIONAL ABSTRACT] Oct 18 2006 09:43
1 NEW! » David "Copaxone allows some MS patients to retain mobility" Oct 19 2006 19:50
1 NEW! » Lora Future-directed thinking and depression in MS [READ LIZZY'S COMMENT!!!] Oct 28 2006 15:03
1 NEW! » Jeannine MS BIKE TREK Oct 19 2006 09:38
1 NEW! » WaterDragon STEM CELL: "Federal government promotes donation of umbilical cords for stem cell transplants" Oct 20 2006 00:51
1 NEW! » Jeannine Development of an anti-IL-17A auto-vaccine... Oct 20 2006 09:05
1 NEW! » Jeannine GREAT PERSONAL STORY: Oct 20 2006 15:17
1 NEW! » Jeannine "Acute leukaemia in two multiple sclerosis patients treated with mitoxantrone" Oct 20 2006 15:21
1 NEW! » Jeannine The Effect of dose and frequency of interferon beta-1a administration Oct 20 2006 15:31
1 NEW! » Jeannine CDP323: NEW DRUG IN PIPLINE Oct 21 2006 09:58
1 NEW! » Jeannine Did you know that Colorado has one of the highest prevalence rates of MS in the US Oct 21 2006 09:59
1 NEW! » Jeannine Write in Candidate Denise Clement will work for free! Oct 21 2006 10:00
1 NEW! » Jeannine Methylthioadenosine Effective in Animal Models of Multiple Sclerosis Oct 22 2006 07:32
1 NEW! » Jeannine UK: cannabis pill test Oct 22 2006 07:34
1 NEW! » Jeannine Clustering of autoimmune diseases in families with a high-risk for MS: Oct 23 2006 07:36
1 NEW! » Jeannine The female to male sex ratio by year of birth has been increasing for at least 50 years Oct 23 2006 07:39
1 NEW! » Jeannine Photography studio is donating fees to MS Oct 23 2006 08:17
1 NEW! » Jeannine Boston Home's 125th Anniversary - Oct 24 2006 09:28
1 NEW! » Jeannine UK...MP's Back MS Campaign Oct 24 2006 09:32
1 NEW! » Jeannine Dutch prosecutors ask highest court to quash appeals court medicinal cannabis decision Oct 24 2006 09:34
1 NEW! » Jeannine MBP8298 Oct 24 2006 09:35
1 NEW! » deleted account Live HealthTalk - 30 Minutes of Q&A with Nurse Piper [sponsored by a drug company] Oct 24 2006 19:50
1 NEW! » Jeannine High-Dose Cyclophosphamide Study: GOOD RESULTS!!! Oct 25 2006 09:32
1 NEW! » Jeannine NEW DRUG IN PIPELINE: MCT-125 Oct 25 2006 09:35
1 NEW! » Jeannine 3 Guys, 3 Bikes, 7,000 Miles Through South America for MS Oct 25 2006 09:39
1 NEW! » Jeannine 14-year old bicyclist rides for MS Oct 26 2006 08:24
1 NEW! » Jeannine Accelerated Cure Project for MS today announced the formation of their MS Repository Oct 26 2006 08:29
1 NEW! » Jeannine A MSnewsChannel.com Video: A TIP FROM HEATHER ON EASING REBIF PAIN Oct 26 2006 09:02
1 NEW! » Jeannine TYSABRI® GOOD FOR LUPUS TOO...PER THIS PRESS RELEASE FROM ELAN Oct 26 2006 09:04
1 NEW! » Jeannine VISIT OUR "TYSABRI NEWS" WEBSITE Oct 26 2006 09:08
1 NEW! » Jeannine Joseph Eisen suffers from Primary Progressive Multiple Sclerosis....AGENGY HELPS WITH HIS LEGAL Oct 27 2006 08:18
1 NEW! » Jeannine Campus Fudraiser....(good idea for other colleges) Oct 27 2006 14:22
1 NEW! » David WATCH VIDEO: Selling CDs as a MS Fundraiser Oct 29 2006 09:03
1 NEW! » Jeannine If a sibling has MS, you are 15 to 25 times more likely to develop it yourself Oct 29 2006 09:16
1 NEW! » Jeannine UK: NO JAIL FOR HUSBAND WHO HELPED WIFE'S SUICIDE Oct 29 2006 09:18
1 NEW! » Jeannine Car enthusiasts, bikers rally MS Oct 29 2006 09:26
1 NEW! » Jeannine UPDATE ON MS CANDIDATE WHOSE OPPONENT MADE A NASTY WHEELCHAIR COMMENT Oct 30 2006 08:32
2 NEW! » Jeannine "MS NO LONGER A DEATH KNELL FOR PATIENTS" Oct 30 2006 08:43
2 NEW! » David WATCH VIDEO PLUS FREE READ OF CHAPTER 1 : Today show host Meredith Vieira talks with Teri Garr Oct 30 2006 20:27
1 NEW! » WaterDragon "Ed Johns says he feels like a new man" [I WOULDN'T LET MY SON DO THIS!-stan] Oct 31 2006 01:11
1 NEW! » Jeannine TYSABRI.....Biogen Idec Third-Quarter Net Rises Sixfold on MS Drugs Oct 31 2006 09:18
1 NEW! » Jeannine DETROIT FUNDRAISER Nov 1 2006 10:08
1 NEW! » Jeannine ABSTRACT FOR DOCS, NURSES Nov 1 2006 10:09
2 NEW! » Jeannine .....control of their health with exercise, even though it might bring short-term discomfort Nov 1 2006 15:05
1 NEW! » Darth Woky ™ GREAT READ: MS afflicts about twice as many females as males Nov 2 2006 01:15
2 NEW! » David Cladribine used to treat some cancers and possibly MS: Brigham Young University Nov 2 2006 19:15
2 NEW! » David I JUST RECEIVED THIS PRESS RELEASE FROM TEVA RE: COPAXONE {NOT IMPORTANT :-)] Nov 2 2006 19:23
2 NEW! » David VOTE: ANOTHER STEM CELL STORY(I can't decide if I should post stem cell stories or not?? -stan) Nov 2 2006 19:33
3 NEW! » David update: DRUG DELAYED BY FDA FOR A MS CONDITION I'VE NOT HEARD OF -HAVE YOU??? -stan Nov 2 2006 19:36
2 NEW! » David MS Linked to Abnormal Liver Test Results Nov 2 2006 19:46
1 NEW! » Rev. cutthroat carnie TYSABRI BAD NEWS:Since July, only 47 of more than 8,500 patients are using Tysabri... Nov 7 2006 08:13
1 NEW! » Jeannine New York City Chapter MS Society: Help Us Reach Our Fundraising Goal for the MS Bike Tour Nov 1 2006 14:43
1 NEW! » Jeannine BAD NEWS ON UCLA PLAYER WE HAVE BEEN REPORTING ON Nov 2 2006 08:27
1 NEW! » Jeannine !!!...Fampridine-SR: WONDERFUL TRIAL RESULTS ON NEW DRUG Nov 2 2006 08:29
2 NEW! » queen_racewife PRESS RELEASE ON NEW DRUG: MBP8298 [TRIALS ARE VERY GOOD OUT OF THE US!!!] Nov 2 2006 08:35
1 NEW! » Mary and Robert GREAT STORY OF PERSEVERANCE Nov 2 2006 10:40
1 NEW! » Jeannine Study sheds light on myelination Nov 3 2006 07:04
1 NEW! » Jeannine FDA Approvals: Interferon-beta-1b (Betaseron) for Use in Early Multiple Sclerosis Nov 3 2006 18:13
1 NEW! » "Gamma Julie" 'miracle drug' is supposedly no good Nov 4 2006 02:01
2 NEW! » Roseanne ENVIRONMENT CAUSE OF WOMEN'S HIGHER RISK OF MS? Nov 4 2006 09:05
1 NEW! » Jeannine cladrabine Nov 4 2006 14:09
2 NEW! » Jeannine MS Society's 'Shining Star Nov 4 2006 14:30
1 NEW! » Jeannine NEW DRUG IN PIPELINE: MBP8298 Nov 4 2006 14:33
3 NEW! » David UK - EXPERTS believe they have discovered a protein which could help create new MS treatments Nov 4 2006 18:14
1 NEW! » Jeannine WONDERFUL STORY OF PERSEVERANCE IN THIS SUNDAY'S NYC MARATHON Nov 5 2006 12:08
1 NEW! » ~Ãngël~™ NPR AUDIO: Studies have found that a six-month Iyengar yoga program helped people with MS comba Nov 5 2006 17:35
2 NEW! » Jeannine "advances on the horizon..." Nov 6 2006 09:12
1 NEW! » Jeannine GREAT ADVICE FOR CAREGIVERS - stan Nov 6 2006 09:28
2 NEW! » Darth Woky ™ (UPDATE ON THIS STORY IS AB0VE) CHURCHILL DOWNS PERSEVERANCE Nov 7 2006 01:22
2 NEW! » "Gamma Julie" Award given to Scott Johnson, President and Founder of the Myelin Repair Foundation Nov 7 2006 04:46
2 NEW! » queen_racewife INTERESTING IMPLANT STUDY....update Nov 8 2006 03:38
1 NEW! » David (READ THE GREAT COMMENTS) TOVAXIN...NEW MS DRUG IN PIPELINE STARTS DOSING Nov 9 2006 22:56
2 NEW! » Lora GOOD INTERVIEW WITH AUTHOR OF NEW BOOK: ABOUT HER MS Nov 10 2006 13:39
2 NEW! » Mary and Robert Man says tai chi gave him second chance at life. Nov 10 2006 17:20
3 NEW! » Jeannine oral Trimesta (estriol)...A NEW MS DRUG IN THE PIPELINE!!!!! [UPDATE]  Nov 10 2006 18:54
1 NEW! » Jeannine STORY OF 37-YEAR OLDS PERSEVERANCE Nov 10 2006 19:00
1 NEW! » Jeannine NEW BROCHURE: Volunteering for a Clinical Trial: Your Guide to Participating in a Trial Nov 10 2006 19:01
1 NEW! » Jeannine ECCO Shoes Plans to Donates $2 Per Pair of Shoes Sold to MS [good idea for US] Nov 10 2006 19:08
1 NEW! » Jeannine 58% of long-term care claimants are younger than 65 and the top five claims causes are MS, Canc Nov 10 2006 19:09
3 NEW! » Jeannine "Advances on the horizon in treating and curing MS" Nov 10 2006 19:15
1 NEW! » Jeannine A medical marijuana ballot in South Dakota Today Nov 10 2006 19:17
1 NEW! » Jeannine study identifies how treatment can limit impact of T-cells in autoimmune diseases  Nov 10 2006 19:19
1 NEW! » Jeannine MS fundraising luncheon in Ne Jersey Nov 10 2006 19:19
1 NEW! » Jeannine Treatment of neuropsychiatric conditions associated with MS Nov 10 2006 19:21
1 NEW! » Jeannine BREEDERS CUP WIN! McLaughlin on his battle with MS (THE STORY ON THIS FROM LAST WEEK IS BELOW) Nov 10 2006 19:23
1 NEW! » Jeannine PERSEVERANCE: PAT KINSLEY GIVE BACK TO KIDS Nov 10 2006 19:27
1 NEW! » Jeannine GREAT AND IMPORTANT STORY ABOUT DOGS AS HELPERS FOR MS PATIENTS - stan Nov 10 2006 19:28
2 NEW! » Jeannine FDA APPROVAL: BETASERON UPDATE Nov 10 2006 19:30
2 NEW! » Jeannine ELK HUNTING & MS STORY Nov 10 2006 19:32
2 NEW! » Jeannine B12 and MS: UK MS SOCIETY EDITORIAL Nov 10 2006 19:33
3 NEW! » Mary and Robert Help fight multiple sclerosis with me - The Bakersfield Voice Nov 11 2006 02:06
2 NEW! » Mary and Robert {PERSEVERANCE}.....Cheri Piekarski's job is a labor of love Nov 11 2006 13:41
1 NEW! » Jeannine MARY MOLDS' MS DOESN'T STOP HER FROM HELPING OTHERS Nov 12 2006 08:05
3 NEW! » ♥Debbie♥ GOOD WHEELCHAIR NEWS: Battle over Payments Cuts by CMS is being won!!!! Nov 13 2006 08:24
3 NEW! » David "I believe that a person who can't read in our society is more handicapped than I am," Merens s Nov 13 2006 20:35
2 NEW! » Key two-headed snake Nov 13 2006 20:42
2 NEW! » MRSMUSTAINE NEW PATENTS FOR MS MED Nov 14 2006 02:08
1 NEW! » "Gamma Julie" Cannabis Study in news this AM Nov 15 2006 01:39
1 NEW! » "Gamma Julie" memory study Nov 15 2006 01:52
3 NEW! » "Gamma Julie" "Research Highlights" from the New York City Chapter of the National Multiple Sclerosis Society Nov 15 2006 01:59
1 NEW! » "Gamma Julie" GREAT ARTICLE...THINGS ABOUT RICHARD PRYOR & HIS DAUGHTER RAIN THAT HAVE NEVER BEEN TOLD!-stan Nov 15 2006 02:17
1 NEW! » "Gamma Julie" GETTING TOUGH ON MEDICINAL POT SELLERS Nov 15 2006 02:29
1 NEW! » queen_racewife SAMANTHA..PERSEVERANCE AND KINDNESS AT 15 YEARS OLD...."SHE IS MY REAL HERO"-stan Nov 15 2006 17:28
2 NEW! » queen_racewife BNC105: PRESS RELEASE ON THIS NEW DRUG IN PIPLINE Nov 15 2006 17:42
4 NEW! » queen_racewife STEM CELL STORY FROM THE UK Nov 15 2006 17:47
1 NEW! » David "laughing and intractable hiccups can occur early in MS" [study] Nov 16 2006 20:02
4 NEW! » David New Wave Of HOPE- Support Group Aims To Aid MS Patients Nov 17 2006 20:25
2 NEW! » David Amy Clawson: Country music artist Nov 17 2006 20:32
1 NEW! » David TYSABRI: Natalizumab Alters T Cell Ratio in MS Patients (Reuters Health) Nov 19 2006 10:09
2 NEW! » Alpha [GREAT READ] Geographical disparity of Diseases Nov 19 2006 18:55
1 NEW! » Jenn MBP8298: NEW DRUG IN PIPELINE Nov 19 2006 20:13
4 NEW! » Jenn ANOTHER CRAZY STORY FROM THE UK: "FREEZE TREATMENT FOR MS" Nov 19 2006 20:24
1 NEW! » Tim Foolery There are a lot of new things in Krystal Hexamer's life: Research Promises New Treatment for MS Nov 20 2006 07:38
4 NEW! » Stacey OUR FRIEND LARRY NEEDS YOUR HELP: BOTH HE AND HIS MOM HAVE MS Nov 24 2006 07:56
3 NEW! » Shell THIS IS WHY I LOVE MySpace...AND MY MySpace FRIENDS - stan Nov 24 2006 11:36
1 NEW! » Mary and Robert Wheelchair bowlers still rolling Nov 18 2006 16:53
1 NEW! » David THIS POST CAME FROM OUR CORRESPONDENT ANNE: A SIMPLE TEST FOR MS Nov 19 2006 10:27
1 NEW! » Darth Woky ™ CLEVELAND CLINIC TIPS ON: STRESS AND MS Nov 20 2006 01:35
3 NEW! » ♥Debbie♥ "FAMOUS PATIENTS AND THE LESSONS THEY TEACH"...THE NEW YORK TIMES Nov 20 2006 05:11
4 NEW! » Tim Foolery Stem cells might cause brain tumors Nov 20 2006 07:22
1 NEW! » WaterDragon {READ THIS!!!-stan} DRUG COMBO SHOWS SHOCKING REVERSAL OF MS SYMPTOMS Nov 21 2006 04:36
1 NEW! » WaterDragon "What if we could actually reverse the damage that MS causes, restoring function..." Nov 21 2006 05:10
1 NEW! » Jeannine Stada said it is no longer to pursue its Interferon-beta project to treat MS Nov 21 2006 07:28
4 NEW! » Shell Clinical Trial Design Nov 22 2006 07:48
4 NEW! » Alpha STUDY FINISHED RE: people's concern about a perceived high rate of MS in Illinois cities Nov 22 2006 11:20
5 NEW! » David New Patent for diagnosing MS Nov 22 2006 13:17
1 NEW! » Roseanne GREAT EXPLANATION OF STEM CELLS AND THEIR POSSIBLE USE IN MS Nov 23 2006 07:37
2 NEW! » Alpha PERSONAL STORY OF THANKSGIVING Nov 23 2006 20:52
3 NEW! » Alpha SOUTH FLORIDA - National MS Health Expo Is November 19th Nov 24 2006 17:06
4 NEW! » Jeannine YOUR COMMENTS HAVE HELPED "FOOL ON THE HILL"...stan Nov 24 2006 19:00
3 NEW! » "Gamma Julie" {first time i've seen a charity benefit solely for low income ms patients-stan} Nov 25 2006 07:08
5 NEW! » Mary and Robert Multiple Sclerosis Society Alert re: funding Nov 25 2006 23:44
3 NEW! » Mary and Robert DACLIZUMAB FOR MS Nov 25 2006 23:46
4 NEW! » queen_racewife GOOD STORY - University of Rochester presses quest for stem cell breakthrough Nov 26 2006 10:50
5 NEW! » Alpha [WOW!!! READ THIS!!-stan] High-tech device helps a martial artist learn how to walk again Nov 26 2006 16:18
2 NEW! » Kendra OUR FRIEND KENDRA NEEDS OUR WISHES OF GOOD LUCK! HER SURGERY IS APPROACHING - stan Nov 27 2006 08:17
5 NEW! » Alpha Results of study on prevalence of MS in Lewistown to be presented Nov 28 2006 08:36
2 NEW! » ♥Debbie♥ "Do you believe in miracles? " By Linda Beck Nov 28 2006 10:02
1 NEW! » ♥Debbie♥ OUR FRIEND AND "STAR COMMENTATOR" KEY HAS GOOD NEWS Nov 28 2006 10:06
3 NEW! » ♥Debbie♥ THIS IS GREAT: FREE BOOKLET FROM THE UK Nov 28 2006 10:14
1 NEW! » ~♥sweet caroline♥~ OUR FRIEND DEBBIE NEEDS A HUG! SHE HAS A MESSAGE FOR EVERYONE Nov 28 2006 21:01
1 NEW! » Francine MS Holiday Gift Guide Nov 29 2006 08:07
8 NEW! » David "Glatiramer acetate therapy for multiple sclerosis" Nov 29 2006 19:30
1 NEW! » David DARTH WOKY: ONE OF MY BEST FRIENDS NEEDS YOUR ADVICE Dec 2 2006 12:38
3 NEW! » ♥Debbie♥ [update-18 comments] JENNIFER NEEDS SUPPORT: "MY LEGS ARE STIFF & LIFELESS" Dec 4 2006 08:14
2 NEW! » Anne SAD STORY FROM TODAYS HEADLINES Dec 5 2006 05:06
4 NEW! » Anne MELISSA NEEDS SUPPORT Dec 5 2006 05:32
2 NEW! » Kendra NO MERCURY RISK IN AMALGAM FILLINGS Dec 5 2006 08:16
2 NEW! » queen_racewife KIDS: "Why are our children's bodies attacking them? Dec 6 2006 02:55
4 NEW! » queen_racewife PERSEVERANCE: GREAT STORY Dec 6 2006 03:07
1 NEW! » queen_racewife HIGH INCIDENCE OF MS IN ILLINOIS TOWN PUZZLES RESEARCHERS Dec 6 2006 03:23
5 NEW! » queen_racewife PERSEVERANCE: GREAT RADIO INTERVIEW Dec 6 2006 03:35
2 NEW! » Shell PERSEVERANCE...Susan Greenop"s personal story Dec 6 2006 04:49
7 NEW! » Alpha STEM CELL STUDY Dec 6 2006 09:32
3 NEW! » (¯`•´¯)Starr(¯`•´¯) ARTISTS FOR MS Dec 6 2006 09:53
8 NEW! » Mich/Neurotrash'd TERI GARR Dec 7 2006 10:18
1 NEW! » Sean GREAT DISCOVERY AT STANFORD MED SCHOOL: Molecule Linked to Autoimmune Disease Relapses Found Dec 8 2006 15:54
2 NEW! » Mary and Robert GIVE CONGRATS TO TIM FOOLERY FOR GETTING A RAISE! Dec 8 2006 19:12
8 NEW! » David Prescription for the Soul Dec 8 2006 21:07
7 NEW! » Alpha GREAT NEW DRUG: Fampridine-SR Dec 9 2006 12:05
7 NEW! » (¯`•´¯)Starr(¯`•´¯) DISABLED STILL FACE OBSTACLES Dec 9 2006 14:31
5 NEW! » Rev UPDATE ON POT IN CANDY BARS FROM YESTERDAY Dec 10 2006 10:57
4 NEW! » ~Ãngël~™ UPDATE: 36 COMMENTS- ADD YOUR STORY & SHARE YOUR ADVICE: MS IS INTERFERING IN ANGEL'S LOVE LIFE Dec 10 2006 11:16
1 NEW! » Wendy SENATE PASSES GREAT NEW BILL FOR MS Dec 11 2006 08:04
5 NEW! » Tim Foolery "Activists are convinced that electrical pollution is making us sick" Dec 11 2006 09:31
6 NEW! » Tim Foolery GREAT STORY OF PERSEVERANCE FROM TODAY'S HEADLINES Dec 11 2006 09:32
1 NEW! » Tim Foolery CONGRATS TO LORA: SHE'S ALMOST DONE WITH LAW SCHOOL Dec 11 2006 09:33
6 NEW! » Tim Foolery A happy fundraising story - stan Dec 11 2006 14:29
2 NEW! » Jenn CONGRATS TO JENN: "I found out last Monday that hubby and I are expecting .2" Dec 11 2006 18:50
7 NEW! » Yvonne UPDATE ON YESTERDAYS TYSABRI STORY: "1000 MS PATIENTS REFUSED TYSABRI: IT COSTS TOO MUCH! Dec 12 2006 06:54
3 NEW! » Renee JILL'S BDAY IS TODAY...PLUS CONGRATS TO HER ON GRAD SCHOOL!! - stan Dec 13 2006 09:43
1 NEW! » WaterDragon 2 IMPORTANT NEW STUDIES ON GRAY MATTER DAMAGE IN MS Dec 14 2006 04:50
6 NEW! » Alpha MS FAMILY BATTLES LYME DISEASE Dec 14 2006 12:14
1 NEW! » Patti (aka Thelma) UPDATE ON MY POST FROM DECEMBER 4TH: "SIF IS GETTING CHEMO TOMORROW" Dec 14 2006 23:18
4 NEW! » Jeannine TYSABRI: RICH WANTS TO TAKE IT ...BUT HAS A QUESTION Dec 15 2006 07:02
5 NEW! » ~Ãngël~™ GREAT STORY ON NEW JERSEY BIKE TEAM Dec 15 2006 09:44
3 NEW! » ~♥sweet caroline♥~ SUPPORT TEAM ALERT: ANGEL HAS HELPED MANY OTHERS-NOW SHE NEEDS OUR SUPPORT - stan Dec 15 2006 16:08
3 NEW! » CARRIE AMAZING NEWS! CONGRATS TO EVERYONE WHO HAS BEEN MAKING COMMENTS! LOOK AT THIS INFO: Dec 15 2006 20:55
7 NEW! » David CONTROVERSIAL CLINIC SHUT DOWN Dec 15 2006 21:40
7 NEW! » Mary and Robert SAD STORY ABOUT JAZZ SINGER Dec 16 2006 14:58
2 NEW! » David "1000 PATIENTS IN THE UK TO BE DENIED TYSABRI: NOT COST EFFECTIVE" Dec 17 2006 12:25
1 NEW! » David BILLY TALLENT: one of my fav bands [my favorite is Hatebreed] - stan Dec 17 2006 13:37
5 NEW! » Jeannine A MESSAGE FROM ONE OF OUR SUPPORT ANGELS: ALPHA...WHO IS STRANDED IN SEATTLE! -stan Dec 18 2006 14:37
4 NEW! » Jeannine TYSABRI FOR CROHN'S DISEASE TOO!!!! Dec 18 2006 14:40
1 NEW! » Jeannine GREAT NEWS ON NEW MS DRUG FOR MS FATIGUE: MCT-125 Dec 18 2006 14:40
5 NEW! » Jeannine GIVE SPHILLY CONGRATS ON GETTING APPROVED FOR A GRANT Dec 18 2006 14:42
6 NEW! » Jeannine "HAPPY NEWS" FROM OUR SUPPORT ANGEL ANNE - stan Dec 18 2006 14:44
2 NEW! » Jeannine SUPPORT GROUP ALERT: I HAVE RECEIVED MANY EMAILS THIS WEEK FROM OUR FRIENDS WHO ARE SAD Dec 18 2006 14:46
3 NEW! » WaterDragon SUPPORT ALERT: "i have been just feeling like why me why did i have to have ms!" - TERI Dec 18 2006 16:57
4 NEW! » SPhilly SUPPORT ALERT: GIVE RainMaker A PAT ON THE BACK FOR STARTING HIS MS TREATMENT - stan Dec 18 2006 22:30
2 NEW! » Darth Woky ™ CONGRATS TO OUR ANGELS OF SUPPORT: YOUR ADVICE HELPED Holy Crip Dec 19 2006 01:32
4 NEW! » <3i data-blogger-escaped--="" data-blogger-escaped-09:57="" data-blogger-escaped-19="" data-blogger-escaped-2006="" data-blogger-escaped-at="" data-blogger-escaped-br="" data-blogger-escaped-coming="" data-blogger-escaped-dec="" data-blogger-escaped-drug="" data-blogger-escaped-glass="" data-blogger-escaped-great="" data-blogger-escaped-looking="" data-blogger-escaped-m="" data-blogger-escaped-new="" data-blogger-escaped-oral="" data-blogger-escaped-soon...hopefully="" data-blogger-escaped-stan="" data-blogger-escaped-the="" data-blogger-escaped-through="" data-blogger-escaped-you="">1 NEW! » (¯`•´¯)Starr(¯`•´¯) 1,039 FRIENDS VISITED OUR BLOG YESTERDAY & READ YOUR 125 COMMENTS!!!!!!!!!!! - stan Dec 19 2006 10:15
4 NEW! » (¯`•´¯)Starr(¯`•´¯) TERI & ALPHA THINK THIS STORY WILL HELP EXPLAIN MS TO YOUR FAMILY: IT'S ALSO ON TYSABRI - stan Dec 19 2006 10:20
1 NEW! » Melissa NEW PAIN DRUG APPROVED FOR MS...IN EUROPE...WHICH MEANS IT WILL HOPEFULLY BE HERE SOON - stan Dec 19 2006 15:10
4 NEW! » Kim SUPPORT ALERT: BOTH SUSAN AND I NEED HELP! - stan Dec 19 2006 19:33
9 NEW! » Jeannine HAPPY HOLIDAY STORY IN TODAY' NEWS -stan Dec 20 2006 09:55
2 NEW! » Jeannine GIVE CHRIS...OUR NEWSEST ANGEL OF SUPPORT A HUG - stan Dec 20 2006 10:05
4 NEW! » Jeannine POSSIBLE NEW MS TREATMENT: SOY!!!!!!!!!!!!!!!! Dec 20 2006 10:27
5 NEW! » Jeannine INTERESTING STUDY ON RURAL VS URBAN USE OF DOCTORS IN MS PATIENTS Dec 20 2006 10:30
4 NEW! » Jeannine DIABETES BREATHROUGH - RELATIONSHIP TO MS? SEE MY POST ABOVE FROM VIVIAN Dec 20 2006 10:34
1 NEW! » Jeannine AN INTERESTING EMAIL ON DIABETES CURE AND I'S RELATION TO MS Dec 20 2006 10:35
7 NEW! » David THIS STORY IS BETTER THAN THE TRASH FICTION BOOKS I LOVE TO READ - stan Dec 20 2006 20:21
6 NEW! » David NEW MS DRUG UPDATE IN THE NEWS: CHR-1103 Dec 20 2006 20:23
4 NEW! » David UPDATE: FDA ADVISORY (WARNING) 2 Rituxan deaths: of Tysabri type..rare brain infection Dec 20 2006 20:30
7 NEW! » There Can Only Be One Me SUPPORT ALERT FOR FRANCINE - SHE HAS HELPED MANY FRIENDS - NOW SHE NEEDS HUGS! - stan Dec 21 2006 06:58
2 NEW! » Jeannine COGNITIVE TRAINING HELPS SENIORS" [STUDY] MAYBE IT WILL HELP MS TOO??? Dec 21 2006 06:59
1 NEW! » Miss Kitty MY MESSAGE TO OUR ANGELS OF SUPPORT- RE: YOUR 2 HOLIDAY GIFTS FROM ME + HELP 4 FRIENDS -stan Dec 21 2006 11:10
7 NEW! » :Vitamin DEE: STORY ON NEW MS DRUG IN THE PIPELINE: NEUROVAX Dec 21 2006 21:31
3 NEW! » queen_racewife READ 42 COMMENTS-MARIES IMPORTANT UPDATE ON HER Dec 22 2006 05:43
2 NEW! » (¯`•´¯)Starr(¯`•´¯) DEBBIE'S CHRISTMAS MESSAGE TO OUR Angels of Support Dec 22 2006 10:03
7 NEW! » (¯`•´¯)Starr(¯`•´¯) GREAT STORY OF A MED STUDENT'S PERSEVERANCE IN TODAYS HEADLINE NEWS - stan Dec 22 2006 10:20
7 NEW! » Anne ANOTHER SUCCESS FOR OUR Angel of Support KELLI'S VIDEO - stan Dec 22 2006 16:55
1 NEW! » Patti (aka Thelma) KISOR...OUR NEWEST ANGEL..HAS A REBIF TIP...ON GIVING YOURSELF A SHOT -stan Dec 22 2006 23:40
6 NEW! » WaterDragon SUPPORT ALERT QUESTION: "what have you heard about mono and ms? - shane Dec 24 2006 07:22
4 NEW! » David A GREAT STORY FROM MED STUDENT SOURCE: "New MS Therapies in Clinical Trials" Dec 24 2006 09:46
7 NEW! » David PERSEVERANCE IN TODAY'S NEWS Dec 24 2006 09:54
6 NEW! » David Romney has said he would end to his political career for his wife, who has MS. Dec 24 2006 10:00
1 NEW! » Luis TYSABRI SUPPORT ALERT: "Please help me Stan!" - JAMIE Dec 25 2006 06:29
4 NEW! » Lisa NEW STUDY ON MS & PREGNANCY Dec 25 2006 12:51
1 NEW! » Chanfb915 High Levels of Vitamin D In the Body May Decrease the Risk of MS: HARVARD PRESS RELEASE Dec 25 2006 18:29
3 NEW! » Mary and Robert ADD YOUR "HAPPY &/or FUNNY STORY" TO THE 31 BELOW: I'M GOING TO PUT THEM IN A SLIDESHOW - stan Dec 27 2006 00:46
1 NEW! » Mary and Robert SUPPORT ALERT UPDATE - 18 COMMENTS: "I am still trying to accept everything (dx Aug 2006)" Dec 27 2006 01:27
2 NEW! » Mary and Robert NEW PHOTOS-CONGRATS TO RENEE: "he popped the big question-he's seen me at my worse with my MS" Dec 27 2006 01:54
2 NEW! » Mary and Robert WELCOME sorormp3: OUR NEWEST Angel...A SUPER Stay-Home Mom and Retired Teacher Dec 27 2006 01:56
2 NEW! » Mary and Robert SUPPORT ALERT: "I'M DEPRESSED: Does anyone know anything about using chemo for MS?" - Valyum Dec 27 2006 01:59
1 NEW! » Mary and Robert OUR 17 YEAR OLD ANGEL ROSE GOT DIAMOND EARRINGS FOR XMAS: NICE BOYFRIEND! - stan Dec 27 2006 02:00
3 NEW! » Mary and Robert "I GOT A JOB OFFER STAN" - YVONNE Dec 27 2006 02:01
5 NEW! » Mary and Robert "a relationship suddenly breaking up. This happened last week-two days before my birthday." Dec 27 2006 02:12
8 NEW! » Mary and Robert "The greatest thing happened to me this past week at work!!!" - PATRICIA Dec 27 2006 02:15
1 NEW! » Mary and Robert "I wonder how I am going to be brave enough to self administer these injections? Dec 27 2006 02:24
4 NEW! » queen_racewife SUPPORT ALERT: "friends & family seem to be "backing off"-not sure how to "deal" with me & MS" Dec 27 2006 03:40
8 NEW! » queen_racewife WELCOME OUR NEWEST SUPPORT ANGEL: AMY Dec 27 2006 03:43
2 NEW! » queen_racewife SUPPORT ALERT: "i pray that i don't have a replapse while with family" - DIERDRE Dec 27 2006 04:03
4 NEW! » queen_racewife GREAT LONG STORY ON MY MAIN MS NEWS SITE - stan [too long 4 this blog] Dec 27 2006 04:05
5 NEW! » queen_racewife LADOSTIGIL (an Alzheimer's drug) for treating MS Dec 27 2006 04:17
3 NEW! » Gypsy Queen GOOD STORY ON EXERCISE FROM TODAY'S NEWS - stan Dec 27 2006 05:34
3 NEW! » Beth NATALIE'S PERSEVERANCE!!! YOUR COMMENTS OF SUPPORT HELPED NATALIE - stan Dec 27 2006 10:44
3 NEW! » David SUPPORT ALERT: "I HAD A MRI..IT SHOWED 1 NEW LESION FOR A TOTAL OF 10" - SUSAN Dec 27 2006 21:23
4 NEW! » David THIS IS A "INDEX OF STORIES" SLIDESHOW THAT IS UNDER CONSTUCTION: CAN U READ THE HEADLINES? Dec 27 2006 21:34
2 NEW! » Anne SUPPORT ALERT: My doctor says I may have MS & Fibromyalgia-does anyone else have both of these? Dec 28 2006 01:09
4 NEW! » HOOLIE 5 NEW TATS TODAY: "TATOOS AGAINST MS" Many have told me tatoos help them deal with MS Dec 28 2006 07:27
4 NEW! » Donna Mojo-"Athos" HAS A MOOD TIP: "I HAVE DAYS WHEN I'M SO LONELY THAT I SIT IN MY ROOM AND CRY" Dec 28 2006 10:25
1 NEW! » "Gamma Julie" SUPPORT ALERT FOR GENEISIS & HER "MS NIGHTS! DO U HAVE THE SAME PROBLEM? TELL US! - stan Dec 28 2006 02:58
1 NEW! » "Gamma Julie" COPAXONE SUPPORT ALERT: JULIE'S HUSBAND IS GETTING LUMPS LIKE A MARBLE @ THE INJECTION SITE!?? Dec 28 2006 03:12
2 NEW! » queen_racewife TYSABRI: HARVARD MED SCHOOL'S TOP 10 STORIES OF 2006 Dec 28 2006 05:28
10 NEW! » ~Ãngël~™ SUPPORT ALERT FOR SANDRA: "I AM SO STRESSED WITH THIS & DON'T KNOW WHAT TO DO" Dec 28 2006 07:49
10 NEW! » Jeannine 1,066 VISITORS & 152 COMMENTS ON OUR BLOG YESTERDAY - stan Dec 28 2006 08:02
6 NEW! » Key MS family's appearance on the ABC television show "Extreme Makeover: Home Edition" Dec 28 2006 12:13
15 NEW! » Katrina (great update: note from Kendra) SUPPORT ALERT: KENDRA NEEDS HUGS AND A NEW DOC!!! -stan Dec 28 2006 12:36
5 NEW! » Yvonne SUPPORT ALERT: "SINCE MY DX MY SEX LIFE HAS BEEN SHIT" DARTH WOKIE Dec 28 2006 12:46
3 NEW! » queen_racewife For kids, MS itself just half the battle: Correctly diagnosing disease can be tricky Dec 28 2006 12:59
15 NEW! » WaterDragon FATIGUE RELIEF: THIS IS ONE OF THE MOST IMPT POSTS I'VE MADE OUT OF 596 I'VE POSTED - stan Dec 28 2006 13:10
4 NEW! » Alpha [4 NEW ANGELS THIS AM] THESE 26 FRIENDS HAVE JOINED OUR 91 ANGELS OF SUPPORT THIS WEEK Dec 28 2006 14:13
16 NEW! » D SUPPORT ALERT FOR OUR NEWEST ANGEL-NANCY WHO HAS "WEIGHT GAIN OF 50 POUNDS" = stan Dec 28 2006 14:19
1 NEW! » Alpha SUPPORT ALERT: CANCER HASN'T STOPPED BRIAN'S WANTING TO BE AN "ANGEL OF SUPPORT" [HUGS! PLEASE]

Labels: Avonex, Betaseron, Copaxone, Rituxan, Tysabri

American Academy of Neurology Meeting: Monoclonal Antibodies Shine in Relapsing-Remitting MS but Not All to Same Degree 

Labels: 500 BEST PML STORIES & STUDIES, PML (Progressive Multifocal Leukoencephalopathy), Rituxan, Tysabri

 Genentech Inc. and Biogen Idec Inc.'s cancer drug Rituxan failed to slow the disabling effects of the most difficult-to-treat form of multiple sclerosis in a large clinical trial.

Rituxan didn't reach its main goal of slowing disability for people with primary progressive multiple sclerosis after almost two years of treatment, compared with a placebo, the companies said in a statement. If the trial had succeeded, it would have made Rituxan the first drug to work against the primary progressive form of MS, or PPMS.

Rituxan, a blood-cancer drug that's also approved for rheumatoid arthritis, generated $2.29 billion in U.S. sales in 2007. It is designed to work by killing inflammatory B cells, a different approach than approved MS drugs. About 400,000 people in the U.S. have MS, and one in 10 have the primary progressive form that gradually damages nerve fibers over time without remissions, according to the National MS Society.

``While the primary results are not what we had hoped, we continue to believe in the potential of B cell therapy for patients living with MS,'' said Michael Panzara, Biogen's vice president and chief medical officer of its neurology strategic business unit.

Genentech, majority-owned by Switzerland's Roche Holding AG, fell 63 cents, or less than 1 percent, to $74.06 at 4 p.m. on the New York Stock Exchange. Cambridge, Massachusetts-based Biogen, a co-promoter of the drug, rose $1.21, or 2 percent to $64.93 on the Nasdaq Stock Market.

Revenue Opportunity

``This would have presented a revenue opportunity of more than 500 million Swiss francs for Roche but was not included in our model or consensus estimates,'' Deutsche Bank analysts including Michael Leuchten said in a note to investors today. ``PPMS is a tough part of MS to treat and nothing has worked in this setting so far.''

Multiple sclerosis is diagnosed when the body's immune system goes awry and begins attacking the fatty insulating tissue around nerve fibers, called myelin, according to the National MS Society.

The Rituxan trial, called Olympus, followed 439 patients for two years after they took an infusion of Rituxan or a placebo. Patients took a repeat course of Rituxan every six months, said Craig Smith, neurology lead clinical scientist in the immunology department at Genentech, in a telephone interview before the announcement.

Side Effects

Patients were monitored for the status of their disability, to see, for example, whether they were losing their ability to walk, see clearly, or maintain strength in their arms, Smith said. A secondary goal of the study looked at whether the drug reduced brain lesions.

More patients had serious side effects on Rituxan than on placebo, Genentech and Biogen said. The rate of serious side effects was about 16.4 percent in the Rituxan group, compared with 13.6 percent on placebo. About 4.5 percent of Rituxan patients had serious infections, compared with 1 percent on placebo. There was some evidence that the drug was working biologically, although the companies didn't specify how much in the statement.

Genentech and Biogen plan to continue analyzing the results and submit them at a future medical meeting, the companies said.

Double Vision

People in the trial were about 48 years old on average, and had been diagnosed with primary progressive MS four to 10 years before enrolling in the study, Smith said. They entered the study with an average disability score of 4 on a scale of 1 to 10, meaning they lacked some coordination, or had some double vision or weakness, although were still able to walk without assistance, he said.

Previously, Rituxan was studied for patients with the most common form of MS, the relapsing, remitting form. That study, called Hermes, found that one in five patients on Rituxan relapsed, while twice as many on placebo had a recurrence in a 48-week clinical trial, according to research published in February in the New England Journal of Medicine.

Existing drugs, including Biogen's Avonex, Bayer AG's Betaseron, Merck KGaA's Rebif and Teva Pharmaceutical Industries Ltd.'s Copaxone, work differently than Rituxan by blunting the attack of immune system T cells. None of the drugs have shown a benefit for patients with the primary progressive form of the disease, Smith said.

Next Steps

The market for MS drugs exceeded $5.5 billion in 2006 and is expected to double by 2013, according to market-research firm Frost & Sullivan in New York. Rituxan costs $20,514 a year for two infusions for patients with rheumatoid arthritis, said Genentech spokeswoman Nikki Levy.

``Right now we are reviewing all the data from Olympus and determining next steps regarding our development program,'' Levy said yesterday in an e-mail.

The company still plans a mid-stage clinical trial of ocrelizumab, a second-generation drug that blocks the same protein on B cells as Rituxan. The newer drug will be studied against the relapsing, remitting form of MS, Levy said.

To contact the reporters on this story: Luke Timmerman in San Francisco at ltimmerman@bloomberg.net

Labels: Avonex, Betaseron, Copaxone, Rituxan